SA-702 Vaccine Adjuvant
SA-702 is a new therapeutic approach with entolimod that employs the immunopotentiating properties of the drug together with alum (aluminum salts) as a vaccine adjuvant. In this context, entolimod’s immune activity would be harnessed to enhance the efficacy of vaccines by eliciting a stronger immune response to the vaccine’s particular antigen.
Many vaccines require an adjuvant to induce sufficient immune response. It is estimated that about one half of 30 of the most common vaccines approved by FDA contain alum as an adjuvant. Until recently, alum was the only adjuvant approved by FDA, but often alum alone does not allow new vaccines to reach sufficient clinical potency.
A shortage of effective and safe adjuvants is a major bottleneck in vaccine development. A newer generation of vaccine boosters combine classic adjuvants mixed with immunomodulators (like entolimod). We have collaborated with academic investigators who have performed preclinical studies that support the adjuvant potential of SA-702 in enhancing vaccine immune and wish to translate these data to clinical studies to document the immunopotentiating effect of the drug.
Cleveland BioLabs, Inc.
73 High Street
Buffalo, NY 14203
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Cleveland BioLabs, Inc.
73 High St.
Buffalo, NY 14203
This policy was last updated on June 15, 2012.